The HOPE project will design and develop safe and innovative polymer-drug conjugates, and evaluate their potential as antiparkinsonian drugs.
The main objective of the project is to synthesize and characterize, from a physicochemical and biological point of view, a new polymer-drug conjugate, composed of poly(ester amide)s (PEAs) and DOPA, as a promising therapeutic agent in the treatment of Parkinson Disease by intranasal administration, improving tolerability and reducing adverse events.
Innovative and custom poly(ester amide)s-levodopa conjugates: synthesis and characterization; Evaluation of the potential of brain-targeted PEAs-DOPA conjugates for Parkinson’s Disease via intranasal administration.
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EC Funding – Total
EC Funding – IPN
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